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Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
[Risk factors that modulate periodontal diseases]
1Division of Oral Infectious Diseases and Immunology, Faculty of Dental Science, Kyushu University.
None:
Periodontal diseases now is a chronic inflammatory disease caused by Gram negative bacterial infection. Recently, it is of interest to evaluate risk factors that modulate initiation and development of this disease. A recent study have suggested that obesity is one of the risk factors. In this regard, most recently, we found that leptin, a regulator of food intake and whole-body energy metabolism, acts as a negative regulator of LPS-induced expression of inflammatory cytokines of macrophages via inhibition of NF-kB.
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