Related Experiment Video
Updated: Aug 19, 2026

Monitoring ER/SR Calcium Release with the Targeted Ca2+ Sensor CatchER+
Published on: May 19, 2017
[Transcriptional regulation of the sarcoplasmic reticulum Ca2+ -ATPase gene]
1Second Department of Internal Medicine, Gunma University School of Medicine.
Abstract:
Sarcoplasmic reticulum Ca(2+)-ATPase is a key protein which takes Ca(2+) up into sarcoplasmic reticulum, thereby controls relaxation of cardiac muscle. The expression level of Ca(2+)-ATPase mRNA is regulated transcriptionally under various pathophysiological conditions. The E-Box, CArG Box, and MCAT element are essential for the muscle-specific transcription of the gene. Egr-1 sites in the proximal regulatory region of the gene are responsible for the decreased expression of Ca(2+)-ATPase mRNA in heart failure. Additionally, both proximal and distal regulatory elements are important for the transcriptional suppression of the gene.
More Related Videos
Related Concept Videos
Regulation of Nuclear Protein Sorting
Cell Specific Gene Expression
ATP Driven Pumps II: P-type Pumps
A typical P-type pump has three cytosolic domains: nucleotide-binding (N), phosphorylation (P), and activator (A) domains. These domains are connected to the membrane-spanning helices by short amino acid segments. ATP hydrolysis and covalent phosphoenzyme intermediate formation are crucial parts of the catalytic cycle. At the highly...
Feedback Regulation of Calcium Concentration
Various transmembrane receptors, such as G protein-coupled receptors (GPCRs), elicit a response to extracellular signals by increasing cytosolic calcium. Activated GPCRs...
RNA Polymerase II Accessory Proteins
ATP Synthase: Mechanism

