[Drug therapy for osteoporosis associated with rheumatoid arthritis (estrogen replacement therapy)]

Various types of drug therapy are available for the management of osteoporosis associated with rheumatoid arthritis. Hormone replacement therapy plays an especially important part in the management of this condition. Although hormone replacement therapy increases lumbar bone mineral density in patients who have osteoporosis and rheumatoid arthritis, similar to those with primary osteoporosis, its effect on femoral bone mineral density remains controversial. Since hormone replacement therapy is also effective for rheumatoid arthritis, it is an important treatment option in patients who also have osteoporosis. Evidence is awaited from studies with new designs, including assessment of fracture risk.