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Updated: Aug 19, 2026

Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes
11:00

Assessment of Sarcoplasmic Reticulum Calcium Reserve and Intracellular Diastolic Calcium Removal in Isolated Ventricular Cardiomyocytes

Published on: September 18, 2017

[Mega clinical trial of calcium channel antagonist in hypertensive patients]

M Shimoyama1

  • 1Department of Cardiovascular Medicine, Sanin Industrial and Accidental Hospital.

Clinical Calcium
|March 19, 2005
PubMed

Insights

Calcium channel blockers effectively lower cardiovascular events and stroke in hypertension patients. However, they may increase risks for coronary heart disease and heart failure compared to other treatments.

Area of Science:

  • Cardiology
  • Pharmacology

Context:

  • Large-scale clinical trials evaluated calcium channel antagonists for hypertension management.
  • Comparative effectiveness against placebo, diuretics, and beta-blockers was assessed.

Purpose:

  • To analyze the cardiovascular outcomes associated with calcium channel antagonist therapy in hypertensive patients.
  • To compare the efficacy and safety of calcium channel antagonists versus other antihypertensive drug classes.

Summary:

  • Calcium channel antagonists reduced cardiovascular events and stroke incidence compared to placebo and other agents.
  • However, these agents were associated with increased risks of coronary heart disease and heart failure relative to diuretics or beta-blockers.

Impact:

  • Calcium channel antagonists remain crucial for achieving blood pressure control and reducing cardiovascular events in hypertension.
  • Further research may be needed to optimize their use and mitigate potential adverse effects.

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