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Updated: Aug 19, 2026

A Simple Pit Assay Protocol to Visualize and Quantify Osteoclastic Resorption In Vitro
Published on: June 16, 2022
[Effects of calcitonin on osteoclast]
1Scientific Affairs & Sales Promotion Dept, Health Care Company, Asahi Kasei Corporation.
None:
Osteoclasts are cells that resorb bone, and calcitonin potently inhibits this bone resorptive activity. While calcitonin does not affect primary osteoclastic differentiation, it does manifest an inhibitory effect on the bone resorptive activity of osteoclasts. It is believed that calcitonin, acting upon calcitonin receptors and through PKA and PKC signal transduction pathways, destroys cytoskeleton components such as podosomes. The "escape phenomenon" seen with osteoclasts is a known issue occurring with the use of calcitonin, and is also believed to arise due to calcitonin receptors and the PKA and PKC signal transduction pathways.
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