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[The effects of calcitonin on osteoclasts morphology]
1Anatomy and Cell Biology of the Hard Tissue, Tissue Regeneration and Reconstruction, Course for Oral Life Science, Niigata University Graduate School of Medical and Dental Sciences.
Abstract:
Calcitonin causes acute and dramatic morphological changes in bone resorbing osteoclasts. The most striking change is the destruction of clear zones and ruffled borders. These structures are formed by the interaction of cytoskeletons and signals transduced from cell-matrix adhesion complexes. Further studies on the structures of cytoskeleton and adhesion complexes in osteoclasts are necessary to elucidate the effects of calcitonin on the morphology of osteoclasts.
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