[Control of the secondary hyperparathyroidism by the suppression of plasma phosphate level in chronic renal failure patients]
Related Experiment Video
Updated: Aug 19, 2026

5/6 Nephrectomy Using Sharp Bipolectomy Via Midline Laparotomy in Rats
Published on: April 4, 2025
1Department of Internal Medicine, Shinrakuen Hospital.
Abstract:
Secondary hyperparathyroidism is inevitable in the chronic renal failure state. The pathogenesis of it is multifactorial, such as hypocalcemia, low level of 1,25(OH)(2)D(3), bone resistance to PTH calcemic action, decreased vitamin D receptor, decreased Ca-sensing receptor, as well as hyperphosphatemia. Recent enthusiastic studies revealed the direct and strong effect of phosphate (P) on PTH secretion. Then, the important role of plasma P suppression in the chronic renal failure patients has been recognized again. A new P binder polycation-polymer "sevelamer" has no calcium (Ca) and no aluminum (Al). It can lower the plasma P level without increase of Ca and Al, and can decrease plasma PTH level simultaneously.
More Related Videos
Related Concept Videos
The Parathyroid Glands
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by producing...
Skeleton and Calcium Homeostasis
Roles of Electrolytes: Calcium and Phosphate
The calcium concentration in blood plasma is primarily regulated...
Hormones and Bone Tissue
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
Antihypertensive Drugs: Potassium-Sparing Diuretics
Acute Kidney Injury V: Interprofessional Care

