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[Drugs that modulate the cellular function of calcium ion].

R Ishikawa1, K Kohama

  • 1Department of pharmacology, Gunma University School of Medicine.

Clinical Calcium
|March 19, 2005
PubMed
Summary

Cellular calcium (Ca2+) signaling is crucial for cell function. This review summarizes drugs targeting proteins involved in calcium regulation, impacting cellular responses to stimuli.

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Area of Science:

  • Biochemistry
  • Cell Biology
  • Pharmacology

Context:

  • Cytoplasmic calcium (Ca2+) concentration is tightly regulated at approximately 10(-7)M.
  • Increases in Ca2+ concentration, triggered by stimuli, activate Ca2+-binding proteins and downstream signaling pathways.
  • These pathways mediate cellular responses to various external signals.

Purpose:

  • To review the effects of drugs targeting key proteins in calcium homeostasis and signaling.
  • To provide a comprehensive overview of pharmacologic interventions affecting calcium-binding proteins.

Summary:

  • This report focuses on drugs targeting proteins essential for maintaining low cytoplasmic Ca2+ levels.
  • It examines the impact of these drugs on Ca2+ pumps, ion exchangers, ion channels, calmodulin, and other Ca2+-binding proteins.
  • The review consolidates information on how these drug targets modulate cellular responses.

Impact:

  • Understanding these drug targets is vital for developing novel therapeutics for diseases involving calcium dysregulation.
  • This summary aids researchers in identifying potential pharmacological strategies for modulating cellular signaling pathways.
  • The findings contribute to the broader knowledge of calcium's role in physiology and disease.

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