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Granulocytic chalone inhibits rapidly proliferating committed murine progenitor cells (CFU-C)
Biomedicine / [Publiee Pour L'A.A.I.C.I.G.]
|April 1, 1979
Abstract:
Bovine leucocyte extract containing the granulocytic chalone inhibited proliferation of rapidly, but not slowly, prliferating murine CFU-C. The precursors of CFU-C, i.e. multipotent colon-forming stem cells (CFU-S), were apparently not affected. Inhibition of proliferation was detected as a decreased killing of DNA synthesizing cells in diffusion chamber cultures by hydroxyurea, after pre-treatment with the extract.