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A case-control study of multiple myeloma in Japan: association with occupational factors

Tomoko Sonoda1, Tadao Ishida, Masamitsu Mori

  • 1Department of Public Health, School of Medicine, Sapporo Medical University, Sapporo, 060 - 8556 Japan. tsonoda@sapmed.ac.jp

Asian Pacific Journal of Cancer Prevention : APJCP
|March 23, 2005
PubMed

Insights

Occupational exposure to chemicals, agriculture, and fishery may increase multiple myeloma (MM) risk. This case-control study in Japan identified significant associations between these factors and MM incidence.

Area of Science:

  • Epidemiology
  • Occupational Health

Background:

  • Multiple myeloma (MM) incidence is rising in Japan.
  • Previous studies suggest occupational and chemical exposures may elevate MM risk.

Purpose of the Study:

  • To investigate the association between occupational factors and multiple myeloma risk in Japan.

Main Methods:

  • A case-control study involving 57 MM cases and 57 matched controls.
  • Data collected via interviews on occupational history and other factors.
  • Statistical analysis using odds ratios (ORs) and 95% confidence intervals (95%CIs), adjusted for smoking.

Main Results:

  • Agriculture and fishery occupations showed a significant association with increased MM risk (OR = 5.89).
  • Occupational exposure to chemical products, including organic solvents and petroleum, was significantly linked to higher MM risk (OR = 8.05).
  • Appendicitis surgery and blood transfusion history showed non-significant associations with decreased risk.

Conclusions:

  • Occupational chemical exposure may contribute to the risk of developing multiple myeloma.
  • Further research is warranted to confirm these occupational risk factors for multiple myeloma.

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