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Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
Published on: January 22, 2019
Quinolinium salt as a potent inhibitor of lymphocyte apoptosis
Sylvie D Barchéchath1, Rommel I Tawatao, Maripat Corr
1Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA 92093-0663, USA.
Bioorganic & Medicinal Chemistry Letters
|March 23, 2005
Abstract:
The synthesis of several quinolinium salts and related compounds and their ability to inhibit glucocorticoid-induced apoptosis in murine thymocytes are described. Interestingly, 1-[2-methoxyimino-2-(4-pyrrolidin-1-yl-phenyl)ethyl]quinolinium bromide (11) showed a potent protective effect with an EC(50) of 0.013 microM, which was at least 300-fold more potent than the reference compound pifithrin-alpha.
