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Mucosal vaccination against diphtheria using starch microparticles as adjuvant for cross-reacting material (CRM197)
Niclas Rydell1, Ingvar Sjöholm
1Department of Pharmacy, Division of Pharmaceutics, University of Uppsala, P.O. Box 580, SE-751 23 Uppsala, Sweden.
Abstract:
Mucosal vaccination has the advantage of eliciting a local mucosal immune response as well as a systemic response. In this investigation, polyacryl starch microparticles were conjugated to diphtheria toxin cross-reacting material (CRM197) as a mucosal adjuvant for oral or intranasal immunisation of mice. Various methods of stabilising CRM197 with formaldehyde were investigated. A good systemic and local mucosal immune response was attained with oral immunisation when CRM197 was treated with a relatively low formaldehyde concentration prior to conjugation to the microparticles. No immune response was seen after intranasal immunisation.
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