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Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
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Ethanol physical dependence is accompanied by up-regulated expression of L-type high voltage-gated calcium channel

Masashi Katsura1, Fumiko Torigoe, Shinsuke Hayashida

  • 1Department of Pharmacology, Kawasaki Medical School, Kurashiki 701-0192, Japan.

Brain Research
|March 23, 2005
PubMed

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Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...