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Updated: Aug 19, 2026

High-Throughput Screening to Obtain Crystal Hits for Protein Crystallography
Published on: March 10, 2023
High-resolution crystallography and drug design
1ABCC, NCI-SAIC-Frederick, MD 21702, USA.
Abstract:
Ultra-high-resolution X-ray crystallography of macromolecules (i.e. resolution better than 0.8 Angstroms) is a rising field that promises to provide new insight into the structure-function relationships of biomacromolecules. The picture emerging from macromolecular structures at this resolution is far more complex than previously understood, requiring for its study improved tools for structure refinement, analysis and annotation. Some of these problems were highlighted during the recent High Resolution Drug Design Meeting (Bischenberg-Strasbourg, France, 13-16 May 2004). We will review here some of the results and discussions that took place during that meeting and elaborate on the trends and challenges ahead in this emerging new field of research.
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