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[Sodium fluoride controlled release system for intra buccal use].
M Diarra1, G Pourroy, A S Diallo
1Laboratoire de Physique, Faculté de Médecine et Pharmacie, Université Cheikh Anta Diop, Dakar, Sénégal. bnimou@yahoo.fr
Dakar Medical
|March 24, 2005
Summary
This study developed a novel hydroxyapatite-based fluoride delivery system for intrabuccal use. The system achieves consistent fluoride release, offering a promising solution for localized oral drug delivery.
Area of Science:
- Biomaterials Science
- Drug Delivery Systems
- Oral Therapeutics
Context:
- Hydroxyapatite (HA) mimics natural bone and teeth composition, making it ideal for intrabuccal drug delivery systems.
- Current intrabuccal drug administration methods require improvement for effective localized treatment.
- Existing orthopedic and dental applications highlight HA's stability and biocompatibility.
Purpose:
- To develop a controlled fluoride release system for intrabuccal administration.
- To formulate stable, biocompatible tablets for targeted delivery to molar or premolar teeth.
- To achieve high local fluoride concentrations for enhanced therapeutic effects.
Summary:
- Tablets (160-200 mg) were formulated using hydroxyapatite, ethylcellulose, and/or Eudragit as a granular matrix.
- Pharmacotechnical properties met pharmacopoeia standards, with no observed disintegration during or after release studies.
- In vitro studies demonstrated a constant, predictable sodium fluoride release rate from the HA-based tablets.
Impact:
- The developed system offers a predictable and stable fluoride release profile for intrabuccal use.
- Histological analyses confirmed the biocompatibility of the hydroxyapatite tablets.
- This innovation holds potential for improved localized oral drug delivery and therapeutic outcomes.