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Phospholipid tubelets.

Bijaya K Mishra1, Colleen C Garrett, Britt N Thomas

  • 1Department of Chemistry, Louisiana State University, Baton Rouge, Louisiana 70803, USA.

Journal of the American Chemical Society
|March 24, 2005
PubMed
Summary
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Electron microscopy reveals that membrane tubules are flattened tubes, not ribbons. These structures exhibit varying degrees of helical twists along their length, impacting their chirality.

Area of Science:

  • Cell Biology
  • Biophysics
  • Microscopy

Background:

  • Cellular structures often exhibit complex morphologies crucial for their function.
  • Phospholipid bilayers form the fundamental basis of cellular membranes.
  • Understanding membrane structure at the nanoscale is key to deciphering cellular processes.

Purpose of the Study:

  • To re-evaluate the structure of membrane tubules using advanced electron microscopy.
  • To investigate the morphology and structural variations of phospholipid bilayer tubules.
  • To characterize the helical and flattened conformations of these tubular structures.

Main Methods:

  • A novel electron microscopy specimen preparation protocol was developed.
  • High-resolution electron microscopy was employed to image the membrane structures.

Related Experiment Videos

  • Morphological analysis focused on identifying flattened and helical tube conformations.

    • Main Results:

    • Presumed phospholipid bilayer membrane ribbons forming tubules are actually flattened tubes.
    • These flattened tubes display alternating helical twists or flat, untwisted segments.
    • Segments with different conformations and chiral senses coexist along single tubes.

    Conclusions:

    • The structure of membrane tubules is more complex than previously assumed, consisting of flattened tubes.
    • The observed structural plasticity, including helical twisting and flattening, may have functional implications.
    • Further research is needed to understand the biological significance of these structural variations and chiral transitions.