Related Experiment Video
Updated: Aug 17, 2026

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
Published on: June 23, 2019
[Stress-limiting properties of a new tetrahydropyrrolopyrazine derivative]
Abstract:
The effect of compound PV-174, selected from a series of tetrahydropyrrolopyrazine derivatives was studied on a model of immobilization stress in rats. Pretreatment with PV-174 decreases the stress-induced involution of thymus and spleen, hypertrophy of cpinephrosis, and gastric ulceration. The drug also blocks the stress-enhanced lipid peroxidation in lungs and myocardium, while not influencing the effect of kenalog (an exogenous glucocorticoid). It is suggested that one of the possible mechanisms of the antistressor effect of PV-174 is related to the drug action upon CNS.
Related Concept Videos
Aromatic Hydrocarbon Anions: Structural Overview
Due to the absence of continuous overlap of p...
Basicity of Heterocyclic Aromatic Amines
Aryldiazonium Salts to Azo Dyes: Diazo Coupling
Basicity of Aromatic Amines
Aromatic Hydrocarbon Cations: Structural Overview
Removing one hydrogen from the intervening CH2 group with both...
Adrenergic Agonists: Chemistry and Structure-Activity Relationship
Aromatic ring substitutions: Substituting the aromatic ring with –OH groups at positions 3 and 4 yields catecholamines (e.g., epinephrine), which have a high affinity for adrenoceptors. Hydrogen bonding between –OH groups and receptors enhances adrenergic activity.
Separation of the aromatic...

