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Related Experiment Videos

Conservation versus parallel gains in intron evolution.

Alexander V Sverdlov1, Igor B Rogozin, Vladimir N Babenko

  • 1National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health 8600 Rockville Pike, Bldg 38A, Bethesda, MD 20894, USA.

Nucleic Acids Research
|March 25, 2005
PubMed
Summary
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Shared intron positions in orthologous genes from animals and plants are primarily due to evolutionary conservation, not parallel gain. This study reveals that parallel intron gain contributes only a small fraction to conserved intron sites.

Area of Science:

  • Genomics
  • Evolutionary Biology
  • Molecular Biology

Background:

  • Orthologous genes across diverse eukaryotes like animals and plants exhibit conserved intron positions, with up to 25-30% shared sites.
  • The relative importance of evolutionary conservation versus the independent acquisition of new introns (parallel gain) in establishing these shared intron positions is not well understood.

Purpose of the Study:

  • To investigate the extent of parallel intron gain at identical sites in orthologous genes from distantly related eukaryotic species.
  • To evaluate the contribution of parallel intron gain versus evolutionary conservation to the observed pattern of shared intron positions.

Main Methods:

  • Assessment of parallel intron gain within the protosplice site model framework.
  • Analysis of intron site conservation compared to random sites.

Related Experiment Videos

  • Computational simulation of intron insertion into protosplice sites.

    • Main Results:

    • Protosplice sites show no significant conservation during eukaryotic sequence evolution compared to random sites.
    • Simulations indicate that parallel intron gain accounts for only a minor proportion (5-10%) of shared intron positions between distantly related species.
    • The observed high frequency of shared intron positions in orthologous genes from animals, fungi, and plants is largely explained by evolutionary conservation.

    Conclusions:

    • The prevalence of introns in the same positions across orthologous genes in distant eukaryotes, including animals, fungi, and plants, is predominantly a result of genuine evolutionary conservation.
    • Parallel intron gain plays a minimal role in establishing these conserved intron positions.
    • The findings support the hypothesis that intron-early mechanisms and conservation are key drivers of intron-exon structure in eukaryotes.