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Anti-estrogenic activity of lignans from Acanthopanax chiisanensis root
Sanghyun Lee1, Hye Hyun Yoo, Xiang Lan Piao
1College of Pharmacy, Seoul National University, Seoul 151-742, Korea. jnp@korea.com
Archives of Pharmacal Research
|March 26, 2005
Abstract:
Anti-estrogenic activity of (-)-sesamin (1), helioxanthin (2), savinin (3), taiwanin C (4), and 3-(3,4-dimethoxybenzyl)-2-(3,4-methylenedioxybenzyl)butyrolactone (5) isolated from the root of Acanthopanax chiisanensis was tested using Ishikawa cells. Among them, compound 3 exhibited anti-estrogenic activity (IC50 = 4.86 microM).
