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Published on: July 11, 2013
[Treatment of atopic dermatitis: practical approach]
G Rossetti1, E Laffitte, P A Eigenmann
1dr.rossetti@bluewin.ch
Insights
Atopic dermatitis (AD) management involves moisturizing, topical treatments, and addressing potential food allergies. New immuno-modulatory macrolides offer alternatives to steroids, but long-term effects require further study.
Area of Science:
- Dermatology
- Pediatrics
- Allergology
Context:
- Atopic dermatitis (AD) is a prevalent chronic skin condition in children.
- Current AD treatment includes moisturizing, parental education, topical anti-infectives, and topical steroids.
- The long-term effects of newer immuno-modulatory macrolides (tacrolimus, pimecrolimus) are not yet fully understood.
Purpose:
- To outline current management strategies for atopic dermatitis.
- To introduce immuno-modulatory macrolides as an alternative to topical steroids.
- To highlight the role of food allergies and the atopy march in AD.
Summary:
- Atopic dermatitis (AD) management focuses on skin hydration, infection control, and topical therapies.
- Immuno-modulatory macrolides are emerging as alternatives to topical steroids, though long-term safety data is pending.
- Identifying and confirming food allergies is crucial before dietary elimination, and physicians should anticipate potential respiratory symptoms due to the atopy march.
Impact:
- Provides a concise overview of current atopic dermatitis treatment approaches.
- Informs clinicians about novel therapeutic options and their current limitations.
- Emphasizes the importance of a holistic approach to managing AD, considering allergies and the broader atopic spectrum.
Abstract:
Atopic dermatitis (AD) is a chronic disease frequent in childhood. The treatment is based on regular moisturizing of the skin, information to the parents on the chronic course with recurrent flares, topical anti-infectious therapy for superinfections and colonization of the skin by staphylococcus aureus, and topical steroids. The immuno-modulatory macrolides (tacrolimus and pimecrolimus) represent a new alternative to topical steroids. These molecules are well tolerated, but theirs effects on the long-term are unknown. A food allergy may be responsible for a AD flare in up to a third of the cases, but the presence of an allergy should be demonstrated before the prescription of an elimination diet. AD is often the first manifestation of atopy: the physician should be aware of the future occurence of respiratory symptoms.
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