Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Improving pulse sequences for 3D DOSY: COSY-IDOSY.

Mathias Nilsson1, Ana M Gil, Ivonne Delgadillo

  • 1School of Chemistry, University of Manchester, Oxford Road, Manchester, UK M13 9PL.

Chemical Communications (Cambridge, England)
|March 26, 2005
PubMed
Summary

Researchers developed a faster method for diffusion-ordered COSY spectroscopy. This new pulse sequence significantly reduces experiment time and improves sensitivity for enhanced spectral analysis.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Robust single-scan ultraselective NMR.

Chemical communications (Cambridge, England)·2026
Same author

General Nuclear Magnetic Resonance Analysis Toolbox for Stats: A Comprehensive Module for Nuclear Magnetic Resonance-Based Chemometrics and Metabolomics.

Analytical chemistry·2026
Same author

Practical Guide and Best Practices for Diffusion NMR Processing With GNAT.

Magnetic resonance in chemistry : MRC·2026
Same author

Real-Time NMR Quantification of Paramagnetic Species during Chemical Reactions.

Analytical chemistry·2026
Same author

NMR-based urinary biomarkers in pediatric primary mitochondrial disorders and chronic kidney disease: shared mitochondrial dysfunction, diverging biosignatures.

Metabolomics : Official journal of the Metabolomic Society·2026
Same author

Dynamic exometabolomics reveals metabolic adaptations of Staphylococcus epidermidis to pH-mimicking skin and bloodstream.

Research in microbiology·2025

Area of Science:

  • Magnetic Resonance Spectroscopy
  • Nuclear Magnetic Resonance (NMR) techniques

Background:

  • Diffusion-ordered spectroscopy (DOSY) is crucial for analyzing molecular diffusion.
  • Conventional DOSY methods can be time-consuming, limiting their application.

Purpose of the Study:

  • To develop an improved pulse sequence for diffusion-ordered COSY (COrrelated SpectroscopY) spectra.
  • To enhance sensitivity and reduce experiment time in DOSY measurements.

Main Methods:

  • Incorporated diffusion encoding directly into the evolution and detection periods.
  • Utilized a gradient-enhanced COSY sequence as the base.
  • Optimized pulse sequence parameters for improved performance.

Main Results:

Related Experiment Videos

  • Achieved significantly improved sensitivity compared to previous methods.
  • Reduced the minimum experiment time by a factor of 32.
  • Demonstrated the efficacy of the integrated diffusion encoding approach.

    • Conclusions:

    • The improved pulse sequence offers a more efficient and sensitive method for DOSY.
    • This advancement facilitates faster and more reliable analysis of molecular diffusion in complex samples.
    • The technique holds promise for various applications in chemistry and materials science.