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Updated: Aug 18, 2026

Establishment and Histological Analysis of Esophageal Organoids Modeling the Progression from Normal to Cancerous Tissues
Published on: May 30, 2025
[Cancer at the esophagogastric junction]
Shoji Natsugoe1, Takashi Aikou
1Dept. of Surgical Oncology and Digestive Surgery, Graduate School of Medicine Sciences, Kagoshima University, Japan.
Abstract:
The definition of cancer at the esophagogastric junction has been discussed for over 30 years. Although at present, two classifications advocated by Nishi or Siewert have been used, these classifications are still controversial from the viewpoints of anatomy, physiology, histology, diagnosis and treatment. We should analyze a large number of patients based on the same definition of cancer at the esophagogastric junction. Adjustment of the Japanese rules for cancer of the esophagus and stomach is necessary, and a treatment strategy should be established for cancer at the esophagogastric junction.
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