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Updated: Aug 18, 2026

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Synthesis, Cellular Delivery and In vivo Application of Dendrimer-based pH Sensors
Published on: September 10, 2013
Fluorescent dendrimers with a peptide cathepsin B cleavage site for drug delivery applications
Sabine Fuchs1, Henning Otto, Stefan Jehle
1Freie Universitat Berlin, Institut fur Chemie/Biochemie, Thielallee 63, D-14195 Berlin, Germany.
Abstract:
The synthesis of a multifunctionally equipped first generation (G1) dendrimer carrying a pentapeptide with a cathepsin[space]B cleavage site, chelating ligands for Pt2+-complexation, and a dansyl fluorescence marker is described and an investigation of its cellular uptake as well as intracellular localization by confocal fluorescence microscopy reported.

