Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Amplifier spurious input current components in electrode-electrolyte interface impedance measurements.

Carmelo J Felice1, Rossana E Madrid, Max E Valentinuzzi

  • 1Departamento de Bioingeniería, Facultad de Ciencias Exactas y Tecnología, Universidad Nacional de Tucumán, Argentina. cfelice@herrera.unt.edu.ar <cfelice@herrera.unt.edu.ar>

Biomedical Engineering Online
|March 31, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Structure-Based Selection of a Tetracycline Derivative for Advanced Biosensor Platforms Targeting Aggregated α-Synuclein in Parkinson's Disease.

ACS chemical neuroscience·2026
Same author

Paper-Based Device for the Colorimetric Determination of Glucose in Whole-Blood Samples Using a Smartphone.

Bioengineering (Basel, Switzerland)·2025
Same author

Simple and promising paper-based electrochemical platform for serological detection of American tegumentary leishmaniasis.

Memorias do Instituto Oswaldo Cruz·2024
Same author

Women in Biosensors Science.

Bioengineering (Basel, Switzerland)·2023
Same author

Smartphone-Based Biosensor Devices for Healthcare: Technologies, Trends, and Adoption by End-Users.

Bioengineering (Basel, Switzerland)·2022
Same author

Syncopation and Its Perceptions.

IEEE pulse·2020

Reducing measurement connection time significantly minimizes drift in impedance microbiology, improving bacterial growth curve reproducibility. This method is more effective than using ultra-low bias current amplifiers for accurate microbial analysis.

Area of Science:

  • Microbiology
  • Electrical Engineering
  • Biophysics

Background:

  • Extended measurement times in impedance microbiology (6-24 hrs) lead to electrode-electrolyte interface drift (approx. 2%/hr).
  • This drift distorts bacterial growth curves, reducing reproducibility and stability.
  • Existing impedance analyzers and bridges are susceptible to this issue.

Purpose of the Study:

  • To identify and mitigate spurious drift in impedance microbiology measurements.
  • To improve the accuracy and reproducibility of bacterial growth curves.
  • To investigate the impact of input circuitry on measurement drift.

Main Methods:

  • Utilized ultra-low bias current amplifiers.
  • Implemented isolating relays for cell selection.

Related Experiment Videos

  • Reduced equipment connection time between readings.
  • Obtained bacterial growth curves to assess quality.

    • Main Results:

    • Reducing connection time decreased drift tenfold, making distortions negligible.
    • Shorter connection times proved more effective than improved amplifiers.
    • Temperature fluctuations (+/- 0.2°C) and frequency had insignificant effects on drift.

    Conclusions:

    • Spurious drift originates from DC input bias offset current or discrete transistors connected to electrodes.
    • Minimizing equipment connection time is the most effective countermeasure.
    • This approach enhances the reliability of impedance microbiology techniques.