Related Experiment Video
Updated: Aug 18, 2026
Use of Two Intracorporeal Ventricular Assist Devices As a Total Artificial Heart
Published on: May 11, 2018
MagScrew total artificial heart in vivo performance above 200 beats per minute
Soren Schenk1, Stephan Weber, Viviane Luangphakdy
1Department of Biomedical Engineering, The Cleveland Clinic Foundation, Cleveland, Ohio 44195, USA.
Purpose:
Downsizing pulsatile devices requires an increase of beat rate if flow capacity is to be maintained. We applied this concept to the preclinical MagScrew total artificial heart (TAH).
Description:
The device fills passively with a stroke volume of 45 ml and beat rates up to 250 beats per minute (bpm).
Evaluation:
Stable hemodynamics were observed during a 30-day bovine implant with a flow of 8.7 +/- 1.2 L/min at beat rates of 204 +/- 18 bpm. Device filling was exceptional up to 250 bpm generating flow of greater than 12 L/min. Beat rate adapted to preload in a way similar to a Frank-Starling response. Left and right atrial pressures were balanced. The aortic pulse pressure was 49-70 mm Hg, which translates to a pulsatility index of 0.49-0.77. Organ functions were preserved and blood damage did not occur.
Conclusions:
Increasing the beat rate while downsizing the MagScrew TAH was successful with strong flow generation by passive filling. Pulsatility was maintained at high beat rates. This innovative approach may be used to develop small pulsatile pumps.
