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Carcinogen-DNA adducts in human alveolar macrophages
A Izzotti1, M Bagnasco, G A Rossi
1Institute of Hygiene and Preventive Medicine, University of Genoa, Italy.
Respiration; International Review of Thoracic Diseases
|January 1, 1992
Abstract:
The occurrence of 7 beta,8 alpha-dihydroxy-(9 alpha,10 alpha)-epoxy-7,8,9,10- tetrahydrobenzo(a)pyrene (BPDE-)-DNA adducts was investigated by synchronous fluorescence spectrophotometry in human pulmonary alveolar macrophages (PAM) collected by bronchoalveolar lavage. In preliminary assays BPDE-DNA adducts were consistently detected in PAM of smokers, whereas samples from nonsmokers did not exhibit specific peaks.