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Large-scale microarray studies of gene expression in multiple regions of the brain in schizophrenia and Alzheimer's

Pavel L Katsel1, Kenneth L Davis, Vahram Haroutunian

  • 1Department of Psychiatry, The Mount Sinai School of Medicine New York, New York 10029 USA.

International Review of Neurobiology
|March 31, 2005
PubMed
Abstract

No abstract available in PubMed .

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DNA Microarrays

Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...