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[Cyclosporin-induced toxic neuromyopathy]
A-M Guennoc1, P Corcia, A Al-Najjar
1Clinique Neurologique, CHU Bretoneau, 37044 Tours. guennoc@med.univ-tours.fr
Revue Neurologique
|March 31, 2005
Summary
Cyclosporine can cause serious nerve and muscle damage (neuromyopathies), even when used alone. This study confirms cyclosporine toxicity as a cause of these debilitating neurological side effects.
Area of Science:
- Nephrology
- Neurology
- Toxicology
Background:
- Cyclosporine is a vital immunosuppressant, but its use is limited by side effects.
- Neurological complications, including neuropathies and myopathies, are known risks, particularly with combination therapies.
Observation:
- A 67-year-old kidney transplant recipient developed rapidly progressing sensorimotor disorders.
- Other potential causes for the neurological symptoms were systematically excluded.
Findings:
- The patient's symptoms improved significantly after the withdrawal of cyclosporine.
- This suggests cyclosporine was the exclusive cause of the observed neuromyopathy.
Implications:
- Cyclosporine monotherapy can induce neuromyopathies at therapeutic doses.
- Clinicians should be vigilant for neurological side effects even in patients receiving cyclosporine alone.
- This highlights the importance of monitoring for neurological toxicity in transplant recipients.