Bioactive triterpenoids from Vochysia pacifica interact with cyclic nucleotide phosphodiesterase isozyme PDE4
Bernard Weniger1, Annelise Lobstein, Byung-Hun Um
1UMR/CNRS 7081, Faculté de Pharmacie, Université Louis Pasteur, Strasbourg, France.
Abstract:
Several species of the genus Vochysia (Vochysiaceae) are used by traditional communities in South America to relieve ailments linked to inflammation, such as skin sores, asthma and pulmonary congestion. As the cAMP phosphodiesterase 4 isozyme (PDE4) is currently considered as an intracellular target for new antiinflammatory drugs, several constituents of Vochysia pacifica Cuatrec., an endemic tree from the Western coast of Colombia, were tested for their ability to inhibit PDE4. Purification of the methanol extract of the stem bark of this species led to the isolation of seven known triterpene derivatives: betulinic acid, sericic acid, 24-hydroxytormentic acid, trachelosperogenin B, 24-hydroxytormentic acid glucosyl ester, quadranoside I and niga-ichigoside F1. One triterpene glycoside, quadranoside I, and two triterpenes, betulinic and sericic acids, exhibited mild inhibitory activity on the isolated PDE4 isozyme.
More Related Videos
07:59A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
07:36Analysis of Raw and Processed Cyperi Rhizoma Samples Using Liquid Chromatography-Tandem Mass Spectrometry in Rats with Primary Dysmenorrhea
Published on: December 23, 2022
Related Concept Videos
GPCRs Regulate Adenylyl Cylase Activity
Two...
Direct-Acting Cholinergic Agonists: Chemistry and Structure-Activity Relationship
The direct-acting...
Transducer Mechanism: Enzyme-Linked Receptors
Major types that are helpful drug targets include:
Phosphoinositides and PIPs
Different phosphoinositides are synthesized and recruited on the cytosolic face of the plasma membrane. The localization of specific phosphoinositides concentrated in separate membrane...
Indirect-Acting Cholinergic Agonists: Mechanism of Action
Reversible inhibitors like edrophonium bind to a specific part of the enzyme called the anionic catalytic site. They form noncovalent bonds, which means they are not strongly attached to the enzyme. This creates a temporary and less stable enzyme–inhibitor complex, leading to...
IP3/DAG Signaling Pathway
