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[Cervical intraepithelial neoplasms. Persistency and recurrence after laser surgery]
S Forsmo1, P Oian, H Stalsberg
1Kvinneklinikken, 9012 Regionsykehuset i Tromsø.
Summary
CO2-laser vaporization for cervical intraepithelial neoplasia (CIN) had higher residual disease and recurrence rates than conization. Conization is a more effective treatment for CIN, with no invasive cancer diagnosed post-treatment.
Area of Science:
- Gynecology
- Oncology
Context:
- Cervical intraepithelial neoplasia (CIN) is a precancerous condition of the cervix.
- The CO2-laser has been used to treat CIN through vaporization or conization.
Purpose:
- To evaluate the effectiveness of CO2-laser vaporization versus conization for treating cervical intraepithelial neoplasia (CIN).
Summary:
- This study analyzed 402 women treated for CIN using CO2-laser vaporization (89 patients) or conization (313 patients) between 1983 and 1988.
- Preoperative diagnosis was CIN III in 214 patients; 5 invasive cancers were diagnosed preoperatively or post-conization.
- Vaporization had higher rates of residual disease (23.6% vs. 4.3%) and recurrence (11% vs. 4.3%) compared to conization.
- Median recurrence time was 11 months; 30 patients required re-treatment. No invasive cancer was diagnosed after treatment.
Impact:
- Conization demonstrates superior efficacy in eradicating CIN compared to vaporization.
- These findings support conization as a preferred method for managing CIN, minimizing residual disease and recurrence risks.