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Liver fibrosis caused by choledocholith to regress after biliary drainage
Zuo-Bing Chen1, Shu-Sen Zheng, Guo-Zhi Hu
1Department of Emergency Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, 79 Qing-chun Road, Hangzhou 310003, Zhejiang Province, China. chenzuobing@hotmail.com
Aim:
To study the correlation between liver fibrosis severity and biliary drainage in patients with choledocholith.
Methods:
A follow-up study on seven patients with liver fibrosis due to choledocholith was made. The data, including biochemical tests (aspartate aminotransferase, alanine aminotransferase) and liver histological features before and after biliary drainage, were collected and studied. The fibrosis severity was scored on a scale from 0 to 3, with 0 denoting none, 1 portal and periportal fibrosis, 2 the presence of numerous fiber septa, and 3 cirrhosis. The average liver fibrosis severity scores of the first and second biopsy were compared with statistical method.
Results:
The first, second liver fibrosis severity scores of these seven patients were 2,1; 2,1; 1,0; 1,1; 2,1; 2,1; 1,0 respectively. The results showed that the average liver fibrosis severity score of the second liver biopsy decreased significantly compared with the first liver biopsy (n = 7, t = 4.25, P<0.05).
Conclusion:
Liver fibrosis due to choledocholith may regress after biliary drainage.
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