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Updated: Aug 18, 2026

Dendritic Spine Quantification Using an Automatic Three-Dimensional Neuron Reconstruction Software
Published on: September 27, 2024
Dendritic spines and long-term plasticity
1Department of Neurobiology, The Weizmann Institute, Rehovot, 76100 Israel. menahem.segal@weizmann.ac.il
Abstract:
A recent flurry of time-lapse imaging studies of live neurons have tried to address the century-old question: what morphological changes in dendritic spines can be related to long-term memory? Changes that have been proposed to relate to memory include the formation of new spines, the enlargement of spine heads and the pruning of spines. These observations also relate to a more general question of how stable dendritic spines are. The objective of this review is to critically assess the new data and to propose much needed criteria that relate spines to memory, thereby allowing progress in understanding the morphological basis of memory.
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