Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dendritic spines and long-term plasticity.

Menahem Segal1

  • 1Department of Neurobiology, The Weizmann Institute, Rehovot, 76100 Israel. menahem.segal@weizmann.ac.il

Nature Reviews. Neuroscience
|April 2, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Synaptic potentiation requires PARP1 activation: prevailing concepts are revisited.

Molecular psychiatry·2026
Same author

Calcium signaling in postsynaptic mitochondria: mechanisms, dynamics, and role in ATP production.

Frontiers in molecular neuroscience·2025
Same author

Distinct Ventral Hippocampus Network Properties in Dissociated Cultures.

Hippocampus·2024
Same author

Cultured Rat Hippocampal Neurons Exposed to the Mitochondrial Uncoupler Carbonyl Cyanide Chlorophenylhydrazone Undergo a Rapid, Presenilin-Dependent Change in Neuronal Properties.

International journal of molecular sciences·2024
Same author

Exposure of Cultured Hippocampal Neurons to the Mitochondrial Uncoupler Carbonyl Cyanide Chlorophenylhydrazone Induces a Rapid Growth of Dendritic Processes.

International journal of molecular sciences·2023
Same author

Dynamic Regulation of Mitochondrial [Ca<sup>2+</sup>] in Hippocampal Neurons.

International journal of molecular sciences·2022

Recent studies explore how changes in dendritic spines, like formation or enlargement, relate to long-term memory. This review proposes criteria to link these structural spine changes to memory formation and stability.

Area of Science:

  • Neuroscience
  • Cell Biology

Background:

  • Dendritic spines are crucial for neuronal communication and synaptic plasticity.
  • The relationship between dendritic spine morphology and long-term memory remains a fundamental question in neuroscience.

Purpose of the Study:

  • To critically assess recent time-lapse imaging data on dendritic spine dynamics.
  • To propose criteria for linking morphological changes in dendritic spines to long-term memory.
  • To advance the understanding of the structural basis of memory.

Main Methods:

  • Review of time-lapse imaging studies of live neurons.
  • Critical analysis of proposed morphological changes related to memory (spine formation, enlargement, pruning).
  • Development of criteria for relating spine morphology to memory.

Related Experiment Videos

Main Results:

  • Identified key morphological changes in dendritic spines potentially linked to memory.
  • Highlighted the need for standardized criteria to interpret these changes.
  • Emphasized the importance of spine stability in memory processes.

Conclusions:

  • Establishing clear criteria is essential for connecting dendritic spine morphology to memory.
  • Further research is needed to validate proposed links and understand the morphological basis of memory.
  • This review provides a framework for future investigations into synaptic plasticity and memory.