Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Pharmacokinetics in the elderly].

F Péhourcq1, M Molimard

  • 1Département de Pharmacologie, CHU Pellegrin-Carreire, Bordeaux.

Revue Des Maladies Respiratoires
|April 2, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Methoxpropamine (MXPr) in powder, urine and hair samples: Analytical characterization and metabolite identification of a new threat.

Forensic science international·2022
Same author

[Introduction of an anticholinesterase drug in the context of myasthenia, in a severe asthmatic patient].

Revue des maladies respiratoires·2021
Same author

The determinants of dyspnoea evaluated by the mMRC scale: The French Palomb cohort.

Respiratory medicine and research·2020
Same author

Suitability of infrared spectroscopy for drug checking in harm reduction centres.

The International journal on drug policy·2020
Same author

Chloroquine and hydroxychloroquine in the management of COVID-19: Much kerfuffle but little evidence.

Therapie·2020
Same author

[Management of mild asthma in 2019-2020: What about new international therapeutic proposals (GINA 2019)?]

Revue des maladies respiratoires·2020
Same journal

[French version of the guidelines for connective tissue disease-associated ILD].

Revue des maladies respiratoires·2026
Same journal

[Pulmonary expression of an asymptomatic lysosomal storage disorder].

Revue des maladies respiratoires·2026
Same journal

[Factors associated with FEV1 evolution in cystic fibrosis patients treated by CFTR modulator tritherapy].

Revue des maladies respiratoires·2026
Same journal

[Subacute pulmonary coccidioidomycosis: A differential diagnosis of lung cancer].

Revue des maladies respiratoires·2026
Same journal

[Relevance of the ACT score in severe asthma with obesity: A pilot study].

Revue des maladies respiratoires·2026
Same journal

[Automated analysis of mandibular movements for the screening of obstructive sleep apnea].

Revue des maladies respiratoires·2026
See all related articles

Aging alters how the body processes drugs (pharmacokinetics), often reducing drug clearance, particularly for kidney-excreted medications. Dosage adjustments are crucial in older adults to ensure safe and effective drug therapy.

Area of Science:

  • Gerontology
  • Pharmacology
  • Physiology

Context:

  • Aging is associated with physiological changes impacting drug pharmacokinetics.
  • These age-related pharmacokinetic alterations occur independently of disease states.
  • Key processes affected include drug absorption, distribution, metabolism, and elimination.

Purpose:

  • To summarize the impact of aging on drug pharmacokinetics.
  • To highlight age-related changes in drug clearance, especially renal clearance.
  • To emphasize the need for dosage adjustments in the elderly.

Summary:

  • Physiological changes during aging can significantly alter drug pharmacokinetics.
  • A consistent age-related change is reduced renal clearance, leading to decreased overall drug clearance.

Related Experiment Videos

  • This is particularly relevant for drugs primarily eliminated unchanged by the kidneys.

    • Impact:

    • Altered drug pharmacokinetics in the elderly can lead to drug toxicity or therapeutic failure.
    • Dosage reduction is often necessary in older patients due to age-related functional decline.
    • Optimizing drug dosages in the elderly is essential for safe and effective pharmacotherapy.