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Diffuse normolipemic plane xanthoma in a 9-year-old boy.
Maja Hofmann1, Kristina Zappel, Uwe Trefzer
1Department of Dermatology and Allergy, Charité, University Medicine Berlin, Germany. maja.hofmann@charite.de
Pediatric Dermatology
|April 5, 2005
Summary
This study details a rare case of normolipemic plane xanthoma in a 9-year-old boy. Early detection and regular follow-up are crucial due to potential links with myeloproliferative disorders.
Area of Science:
- Dermatology
- Pediatric Pathology
Background:
- Normolipemic plane xanthoma (NPX) is typically diagnosed in adults.
- NPX presents as yellowish, flat xanthomatous deposits in the skin.
Observation:
- A 9-year-old boy presented with disseminated, asymptomatic, flat, yellow-brown plaques (2-3 cm).
- Histopathology confirmed xanthoma with CD68+ foam cells and Touton giant cells.
Findings:
- The patient exhibited no signs of systemic involvement or dyslipidemia.
- This case represents an atypical presentation of NPX in a pediatric patient.
Implications:
- NPX in children may precede serious myeloproliferative disorders like leukemia or lymphoma.
- Regular monitoring of pediatric NPX cases is essential for early detection of underlying hematologic conditions.