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Septic arthritis due to Salmonella enteritidis associated with infliximab use

Ioannis Katsarolis1, Sotirios Tsiodras, Periklis Panagopoulos

  • 1Fourth Department of Internal Medicine, Attikon University General Hospital, Athens University Medical School, Athens, Greece. ikatsarolis@yahoo.com

Scandinavian Journal of Infectious Diseases
|April 5, 2005
PubMed

Insights

A patient on infliximab for rheumatoid arthritis developed septic arthritis from Salmonella enteritidis. Treatment required antibiotics and surgery, highlighting rare Salmonella infection risks with infliximab.

Area of Science:

  • Immunology
  • Infectious Diseases
  • Rheumatology

Background:

  • Rheumatoid arthritis (RA) is a chronic autoimmune disease.
  • Infliximab is a biologic therapy targeting tumor necrosis factor-alpha for RA treatment.
  • Immunosuppression associated with biologics can increase infection risk.

Observation:

  • A unique case of septic arthritis caused by Salmonella enteritidis is reported.
  • The patient was undergoing treatment with infliximab for rheumatoid arthritis.
  • Septic arthritis presented as a rare manifestation in this context.

Findings:

  • Salmonella enteritidis was identified as the causative agent of septic arthritis.
  • Successful eradication of the infection necessitated a combination of antimicrobial chemotherapy and surgical intervention.
  • This case underscores the potential for rare Salmonella infections in patients on infliximab therapy.

Implications:

  • Physicians must consider rare Salmonella manifestations in patients using infliximab.
  • Awareness is crucial, particularly in regions where Salmonella is endemic.
  • This highlights the importance of vigilant monitoring for infections in immunosuppressed patients.

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