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KEEPS: The Kronos Early Estrogen Prevention Study.

S M Harman, E A Brinton, M Cedars

    Climacteric : the Journal of the International Menopause Society
    |April 5, 2005
    PubMed
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    Early hormone therapy may prevent cardiovascular disease in women. The Kronos Early Estrogen Prevention Study (KEEPS) investigates if starting hormone therapy near menopause onset benefits heart health.

    Area of Science:

    • Cardiovascular Science
    • Endocrinology
    • Women's Health

    Background:

    • Observational studies suggested hormone therapy (HT) reduces cardiovascular disease (CVD) risk.
    • Recent trials (WHI, HERS) found HT ineffective or harmful for established CVD or late-stage menopause.
    • A new hypothesis suggests early HT initiation near menopause onset may prevent subclinical CVD.

    Discussion:

    • The Kronos Early Estrogen Prevention Study (KEEPS) tests early HT intervention in women aged 42-58 within 36 months of their final menstrual period.
    • KEEPS evaluates conjugated equine estrogens and transdermal estradiol with progesterone against placebo.
    • Primary endpoints include carotid intimal medial thickness progression and coronary calcium accrual.

    Key Insights:

    • KEEPS aims to determine if early HT initiation, unlike previous trials, offers cardiovascular benefits.

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  • The study focuses on preventing subclinical CVD progression in early postmenopausal women.
  • Findings could reshape hormone therapy guidelines for menopausal women's heart health.

    • Outlook:

    • KEEPS is a 5-year, multicenter trial with 720 planned participants, concluding in 2010.
    • Results will clarify the role of early hormone therapy in cardiovascular disease prevention.
    • This research addresses a critical gap in understanding menopausal hormone therapy and long-term cardiovascular outcomes.