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Generation of a Rat Model of Acute Liver Failure by Combining 70% Partial Hepatectomy and Acetaminophen
Published on: November 27, 2019
Mechanistic classification of liver injury
1College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606, USA. john.cullen@ncsu.edu
Abstract:
Toxic injury occurs in the liver more often than any other organ. This can be attributed to the fact that virtually all ingested substances that are absorbed are first presented to the liver and that the liver is responsible for the metabolism and elimination of many substances. Drug-induced liver injury has become a serious health problem in contemporary society. Moreover, liver toxicity is a significant impediment to development of new pharmaceuticals. A classification of liver injury is presented as a means to better understand the spectrum of known mechanisms of liver injury and to assist in discovering novel pathways of toxic liver injury.
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