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Updated: Jul 28, 2026
Site-Directed Immobilization of Bone Morphogenetic Protein 2 to Solid Surfaces by Click Chemistry
Published on: March 29, 2018
Bone regeneration in the rat mandible with bone morphogenetic protein-2: a comparison of two carriers
Oneida A Arosarena1, Wesley L Collins
1Division of Otolaryngology, Department of Surgery, University of Kentucky Medical Center, 800 Rose Street, Room C236, Lexington, KY 40536-0293, USA. oaaros2@pop.uky.edu
Objective:
To compare mandibular bone regeneration with bone morphogenetic protein-2 (BMP-2) delivered with two carriers: a hyaluronic acid polymer (HY), and a collagen carrier complexed with calcium hydroxyapatite and tricalcium phosphate (collagen/HA/TCP).
Study Design:
Defects were created in the bilateral mandibular bodies of 16 Sprague-Dawley rats. The defects were filled with the HY carrier, the HY carrier loaded with BMP-2, the collagen/HA/TCP carrier, or the collagen/HA/TCP carrier loaded with BMP-2. Animals were euthanatized after 6 weeks, and the hemi-mandibles were analyzed histomorphologically.
Results:
Specimens containing BMP-2 had significantly larger new bone and marrow volumes than control specimens. Specimens in the hyaluronan/BMP-2 group tended to have larger volumes of new bone and osteoid than collagen/HA/TCP/BMP-2 specimens, though these differences were not statistically significant.
Conclusion:
The HY and collagen/HA/TCP carriers had comparable efficacy for bone healing with BMP-2.
Significance:
Bone morphogenetic proteins can be delivered with commercially available alloplasts as osteogenic bone substitutes for the repair of craniofacial bone defects.
Ebm Rating:
B-2.
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