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Updated: Aug 18, 2026

A Fluorescence-based Protocol for Preliminary Screening of Protein Synthesis Inhibitors from Natural Sources
Published on: January 27, 2026
Prospective exploration of synthetically feasible, medicinally relevant chemical space
Stephan C Schürer1, Prashant Tyagi, Steven M Muskal
1Sertanty, Inc., 9381 Judicial Drive, Suite 200, San Diego, California 92121, USA.
Abstract:
We describe a novel approach to direct the exploration of chemical space in an effort to balance synthetic accessibility and medicinal relevancy prior to experimental work. Reaction transforms containing empirical reactivity and compatibility information are dynamically assembled into reaction sequences (vProtocols) utilizing commercially available starting material feedstock. These vProtocols are evolved and optimized by a genetic algorithm, which leverages fitness functions based on predicted properties of generated molecular products. We present the underlying concepts, methodology and initial results of this prospective approach.
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