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Updated: Jul 31, 2026

Native Cell Membrane Nanoparticles System for Membrane Protein-Protein Interaction Analysis
Published on: July 16, 2020
NMR experiments on aligned samples of membrane proteins
A A De Angelis1, D H Jones, C V Grant
1Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla 92093, USA.
Abstract:
NMR methods can be used to determine the structures of membrane proteins. Lipids can be chosen so that protein-containing micelles, bicelles, or bilayers are available as samples. All three types of samples can be aligned weakly or strongly, depending on their rotational correlation time. Solution NMR methods can be used with weakly aligned micelle and small bicelle samples. Solid-state NMR methods can be used with mechanically aligned bilayer and magnetically aligned bicelle samples.

