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Kidney preservation with IGL-1 solution: a preliminary report.
L Badet1, P Petruzzo, N Lefrançois
1Service de Chirurgie et Medicine de la Transplantation, Hopital Edouard Herriot, Lyon, France.
Transplantation Proceedings
|April 6, 2005
Summary
The new IGL-1 kidney preservation solution shows improved outcomes compared to the University of Wisconsin (UW) solution. IGL-1 resulted in lower delayed graft function and better early renal function in transplanted kidneys.
Area of Science:
- Nephrology
- Transplantation Immunology
- Organ Preservation
Background:
- The University of Wisconsin (UW) solution is the standard for kidney preservation.
- A novel solution, IGL-1, modifies UW solution's composition with inverted K/Na concentrations and different colloid agents.
Purpose of the Study:
- To evaluate the clinical outcomes of kidneys preserved using the IGL-1 solution.
- To compare IGL-1 preservation with the traditional UW solution in local kidney transplants.
Main Methods:
- A prospective study comparing 37 kidneys preserved in IGL-1 versus 33 in UW solution.
- Evaluation of delayed graft function (DGF), serum creatinine, urine output, and creatinine clearance.
- Post-reperfusion biopsies assessed apoptosis.
Main Results:
- IGL-1 showed a lower DGF incidence (5.71%) than UW (13.79%).
- Significantly lower postoperative creatinine levels and superior creatinine clearance were observed in the IGL-1 group.
- Fewer apoptotic cells were found in IGL-1 preserved kidneys.
Conclusions:
- The IGL-1 solution demonstrates potential superiority for immediate post-transplant outcomes.
- IGL-1 may offer advantages over UW solution in kidney preservation, warranting further investigation.