Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Conjunction revisited.

Karl J Friston1, William D Penny, Daniel E Glaser

  • 1The Wellcome Department of Imaging Neuroscience and Institute of Cognitive Neuroscience, University College London, 17 Queen Square, London, WC1N 3AR, UK.

Neuroimage
|April 6, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The paradox of the self-studying brain.

Physics of life reviews·2025
Same author

Stimulus-repetition effects on macaque V1 and V4 microcircuits explain gamma-synchronization increase.

bioRxiv : the preprint server for biology·2024
Same author

Supervised structure learning.

Biological psychology·2024
Same author

Temporal dynamics of white and gray matter plasticity during motor skill acquisition: a comparative diffusion tensor imaging and multiparametric mapping analysis.

Cerebral cortex (New York, N.Y. : 1991)·2024
Same author

Homo erectus' slowly broadening Zone of Bounded Surprisals opened the way to technological culture: Reply to comments on "'Snakes and ladders' in palaeoanthropology: From cognitive surprise to skilfulness a million years ago," by.

Physics of life reviews·2024
Same author

Reliability of dynamic causal modelling of resting-state magnetoencephalography.

Human brain mapping·2024
Same journal

Investigating the Neural Origins of Ear-EEG: A Correlation Study Using Scalp EEG Source Reconstruction.

NeuroImage·2026
Same journal

Hysteresis effects in visual and auditory perception and the comparison of underlying neural mechanisms - an EEG study.

NeuroImage·2026
Same journal

Short-term audio-tactile training affects cortical auditory speech-envelope tracking for incongruent but not congruent stimuli.

NeuroImage·2026
Same journal

Dissociable Neurocognitive Mechanisms of State and Trait Anxiety in Working Memory: Threat-Induced Alterations in Decision Dynamics and Attenuation of Large-Scale Network Reconfiguration.

NeuroImage·2026
Same journal

Neuro-Ocular Amyloid Characterization in Alzheimer's Disease via Cross-Site PET-MRI and Hierarchical Cross-Attention Driven Multimodal Representation Learning.

NeuroImage·2026
Same journal

Whole-brain network dynamics underlying intolerance of uncertainty.

NeuroImage·2026
See all related articles

This study revisits conjunction analysis in imaging data, reformulating hypotheses to better control false-positive rates (FPR). It proposes a more flexible approach for cognitive conjunctions, improving analysis in neuroimaging software.

Area of Science:

  • Neuroimaging analysis
  • Statistical inference in brain imaging

Background:

  • Current conjunction analysis methods in neuroimaging may not adequately control false-positive rates (FPR).
  • Previous approaches, like those using minimum statistics, often test for k=0 null hypotheses, which can be problematic for conjunctions of multiple effects (k=n).
  • Nichols et al. proposed a conservative supremum P-value method for FPR control in k=n conjunctions.

Purpose of the Study:

  • To revisit and refine the conceptual issues in conjunction analysis for imaging data.
  • To reformulate the conjunction of null hypotheses as a conjunction of k or more effects.
  • To propose a more statistically efficient and less conservative method for cognitive conjunctions.

Main Methods:

  • Revisiting conceptual issues in conjunction inference discussed by Nichols et al.

Related Experiment Videos

  • Reformulating the conjunction of null hypotheses from k=0 to k>=0.
  • Distinguishing between congruent and incongruent contrasts.
  • Introducing a generalized conjunction test for k>u effects, where u represents uninteresting effects.

    • Main Results:

    • The standard k>0 inference is sufficient for congruent contrasts.
    • A more general inference (k>u) is proposed and sufficient for incongruent contrasts, commonly used in cognitive conjunctions.
    • This generalized approach offers improved control over false-positive rates compared to overly conservative methods.

    Conclusions:

    • The standard approach to conjunction analysis needs refinement, especially for cognitive studies.
    • The proposed k>u test provides a more flexible and statistically sound method for analyzing conjunctions of incongruent contrasts.
    • This work has motivated updates to SPM software, enabling the implementation of the more general conjunction test.