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A new human interferon-gamma mutant harboring EGF receptor-interfering sequence possesses high antiproliferative
1National Laboratory of Molecular Virology and Genetic Engineering, Chinese Academy of Preventive Medicine, Beijing.
Science in China. Series B, Chemistry, Life Sciences & Earth Sciences
|January 1, 1992
Abstract:
An interferon gamma (IFN-gamma) mutant gene harboring an additional epidermal growth factor (EGF) sequence at its 3' terminal was constructed and highly expressed in E. coli by using pBV220 as a vector. The new fusion protein-IFN-gamma-EGF possesses not only high antiviral activity, but also high antiproliferative effect as demonstrated by 3H-TdR incorporation method using CN II cells which are rich in EGF receptors.