Structural chemoproteomics and drug discovery
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Updated: Aug 18, 2026

Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
Published on: December 1, 2020
Dongkyu Shin1, Yong-Seok Heo, Kyung Joo Lee
1CrystalGenomics, Inc., Asian Institute for Life Sciences, 388-1 Pungnap-dong, Songpa-gu, Seoul, 138-736, Korea.
Abstract:
Our laboratories have developed several technologies to accelerate drug discovery process on the basis of structural chemoproteomics. They include SPS technology for the efficient determination of protein structures, SCP technology for the rapid lead generation and SDF technology for the productive lead optimization. Using these technologies, we could determine many 3D structures of target proteins bound with biologically active chemicals including the structure of phosphodiesterase 5/Viagra complex and obtain highly potent compounds in animal models of obesity, diabetes, cancer and inflammation. In this paper, we will discuss concepts and applications of structural chemoproteomics for drug discovery.
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