Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Platelet-vessel wall interactions in the microcirculation.

Anitaben Tailor1, Dianne Cooper, D Neil Granger

  • 1Department of Molecular & Cellular Physiology, Louisiana State University Health Science Center, Shreveport, 71130, USA.

Microcirculation (New York, N.Y. : 1994)
|April 9, 2005
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Interleukin-6 blockade modulates monocyte recruitment to protect against diastolic dysfunction associated with inflammatory arthritis.

Arthritis research & therapy·2026
Same author

Comparative Assessment of Whole Organ Tissue Processing Methods for the Isolation of Extracellular Vesicles From Intact Organs.

Journal of extracellular vesicles·2025
Same author

Formyl-peptide receptor type 2 activation mitigates heart and lung damage in inflammatory arthritis.

EMBO molecular medicine·2025
Same author

Publisher Correction: The glucose transporter 2 regulates CD8+ T cell function via environment sensing.

Nature metabolism·2025
Same author

Senescent endothelial cells promote pathogenic neutrophil trafficking in inflamed tissues.

EMBO reports·2024
Same author

β1-Integrin-Mediated Uptake of Chondrocyte Extracellular Vesicles Regulates Chondrocyte Homeostasis.

International journal of molecular sciences·2024
Same journal

Beyond Viral Control: Tenofovir's Hidden Impact on Blood-Brain Barrier Endothelial Cells.

Microcirculation (New York, N.Y. : 1994)·2026
Same journal

Carbon Dioxide Concentration Alters the Dynamics of Oxygen-Mediated Capillary Blood Flow Responses in Skeletal Muscle.

Microcirculation (New York, N.Y. : 1994)·2026
Same journal

Diabetes Upregulates BK<sub>Ca</sub> Channels in Pulmonary Arterial Smooth Muscle by Altering the Local Control Mechanism of the Pore-Gate Domain.

Microcirculation (New York, N.Y. : 1994)·2026
Same journal

Evaluation of Red Blood Cell Biomechanics in the Setting of Cancer-Associated Anemia and Chemotherapy.

Microcirculation (New York, N.Y. : 1994)·2026
Same journal

ZEB1 Modifies VE-Cadherin Signaling in Lymphatic Endothelial Cells.

Microcirculation (New York, N.Y. : 1994)·2026
Same journal

Anisodamine Hydrobromide Ameliorates Pulmonary Microcirculatory Dysfunction in Septic Rats.

Microcirculation (New York, N.Y. : 1994)·2026
See all related articles

Platelet adhesion in microcirculation involves key molecules and shear forces. Nitric oxide and superoxide regulate this process, impacting tissue injury in disease models.

Area of Science:

  • Biomedical science
  • Cardiovascular research
  • Hematology

Background:

  • Platelet adhesion in microcirculation is crucial in various human disease models.
  • Key adhesion pathways include P-selectin-PSGL-1, GPIIb/IIIa-fibrinogen-ICAM-1, and vWF-GPIba.
  • Platelet-leukocyte interactions significantly influence platelet-vessel wall dynamics.

Purpose of the Study:

  • To define the molecular mechanisms and physiological regulation of platelet adhesion in microcirculation.
  • To understand the role of platelet adhesion in the pathogenesis of tissue injury.

Main Methods:

  • Utilizing various animal models of human disease.
  • Characterizing platelet adhesion molecules and pathways.
  • Investigating the influence of shear forces and physiological regulators (nitric oxide, superoxide).

Related Experiment Videos

Main Results:

  • Identified major platelet adhesion pathways: P-selectin-PSGL-1, GPIIb/IIIa-fibrinogen-ICAM-1, and vWF-GPIba.
  • Demonstrated the significant contribution of platelet-leukocyte binding to adhesion.
  • Confirmed the influence of shear forces on platelet adhesion.
  • Revealed nitric oxide as an inhibitor and superoxide as a promoter of platelet adhesion.

Conclusions:

  • Platelet adhesion mechanisms are well-defined in microcirculation models.
  • Physiological regulators like nitric oxide and superoxide play critical roles.
  • Platelet-vessel wall interactions are implicated in initiating and progressing tissue injury in disease.