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Related Experiment Videos

Systemic hypovolemia after subarachnoid hemorrhage.

G A Brazenor1, M J Chamberlain, A W Gelb

  • 1Department of Anesthesia, University Hospital, The University of Western Ontario, London, Ontario, Canada.

Journal of Neurosurgical Anesthesiology
|March 1, 1990
PubMed
Summary

Decreased red cell volume may precede neurological deterioration in subarachnoid hemorrhage patients. Falls in systemic vascular resistance might divert blood flow from the brain, worsening outcomes.

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Area of Science:

  • Neurology
  • Cardiovascular Physiology

Background:

  • Subarachnoid hemorrhage (SAH) poses significant risks for neurological and cardiovascular complications.
  • Monitoring hemodynamic and fluid balance is crucial for managing SAH patients.

Purpose of the Study:

  • To investigate the relationship between circulating blood volume, cardiovascular dynamics, and neurological deterioration in SAH patients.
  • To identify potential premonitory indicators of neurological decline.

Main Methods:

  • Intensive monitoring of two SAH patients, including red cell volume, plasma volume, total blood volume, cardiac output, central venous pressure, and pulmonary capillary wedge pressure.
  • Observation of neurological status and cardiovascular parameters over time.

Main Results:

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  • Both patients experienced acute neurological deterioration.
  • A decline in red cell volume was observed preceding neurological deterioration in both patients.
  • One patient showed a nearly 50% decrease in plasma and total blood volume before deterioration.
  • Falls in systemic vascular resistance occurred prior to neurological decline in both patients, potentially affecting cerebral perfusion.

Conclusions:

  • Red cell volume reduction may serve as an early warning sign for neurological deterioration in SAH.
  • Decreased systemic vascular resistance could compromise cerebral blood flow, contributing to neurological decline after SAH.