Repeat hepatectomy for recurrent colorectal metastases

Area of Science:

• Hepatobiliary Surgery
• Surgical Oncology
• Colorectal Cancer Management

Background:

• Hepatic metastases from colorectal cancer often recur after initial resection.
• Repeat hepatectomy is a potential treatment option for liver recurrence.
• Assessing the safety and efficacy of repeat hepatectomy is crucial.

Purpose of the Study:

• To evaluate the risks and benefits of repeat hepatectomy for colorectal cancer hepatic metastases.
• To determine survival outcomes and prognostic factors for patients undergoing repeat liver resection.

Main Methods:

• Retrospective review of 106 patients undergoing hepatectomy for colorectal cancer liver metastases over 10 years.
• Analysis of outcomes for 27 patients who underwent repeat hepatectomy due to liver recurrence.
• Assessment of complications, perioperative mortality, survival rates, and prognostic factors including disease-free interval (DFI).

Main Results:

• No perioperative mortality was observed after either first or second hepatectomy.
• The median survival after repeat hepatectomy was 41 months, with a 5-year survival rate of 48.7%.
• A disease-free interval (DFI) exceeding one year was significantly associated with improved outcomes (P = 0.047).

Conclusions:

• Repeat hepatectomy for recurrent colorectal cancer liver metastases can be performed safely with acceptable morbidity and mortality.
• Repeat hepatectomy can prolong survival, particularly when a disease-free interval of over one year is achieved.
• A DFI > 1 year is a significant predictor of favorable outcomes after repeat hepatectomy for liver metastases.