Preparing for efficacy trials of vaginal microbicides in Indian women
Smita Joshi1, Suniti Solomon, Kenneth Mayer
1National AIDS Research Institute, G-73, MIDC, Post Box 1895, Bhosari, Pune 411 026, India. sjoshi@nariindia.org
Abstract:
Vaginal microbicides are topical compounds that are expected to protect women against vaginal transmission of HIV and other sexually transmitted pathogens. A large number of compounds are being evaluated as possible microbicides. Considering the spread of the HIV epidemic among women in India, clinical trials on microbicides starting from the Phase I safety and acceptability studies to Phase III efficacy trials are important. Conducting efficacy trials is a major endeavour and this review discusses challenges and issues and the preparatory steps to make such efficacy trials possible in India.
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