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Peutz-Jeghers syndrome. A case report

Matjaz Homan1, Zvezdana Dolenc Strazar, Rok Orel

  • 1University Pediatric Clinic, Vrazov trg 1, 1000 Ljubljana. matjaz.homan@guest.arnes.si

Acta Dermatovenerologica Alpina, Pannonica, Et Adriatica
|April 9, 2005
PubMed

Insights

Peutz-Jeghers syndrome (PJS) is a rare genetic disorder causing gastrointestinal polyps and characteristic skin pigmentation. Early and aggressive screening is crucial for managing complications like intussusception and preventing cancer.

Area of Science:

  • Gastroenterology
  • Genetics
  • Pediatric Medicine

Background:

  • Peutz-Jeghers syndrome (PJS) is an autosomal dominant disorder characterized by hamartomatous polyposis in the GI tract.
  • Clinical manifestations include mucocutaneous pigmentation (lips, buccal mucosa) and gastrointestinal polyps.

Observation:

  • A case report details a 10-year-old girl presenting with intussusception.
  • Intussusception was caused by a hamartomatous polyp, a common complication in PJS.

Findings:

  • PJS patients face recurrent intussusception, often requiring surgical intervention (laparotomies).
  • There is a significantly increased risk of both gastrointestinal and non-gastrointestinal malignancies.

Implications:

  • Aggressive surveillance is vital to prevent cancer development and short bowel syndrome.
  • Recommendations include biennial upper/lower endoscopy from age 10 and annual extra-intestinal cancer screening (ultrasound, breast/testicular exams) from the second decade of life.

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