Related Experiment Videos
[Genetic factors predisposing to fibrosis in systemic sclerosis]
B Granel1, C Chevillard, A Dessein
1Inserm U 399, faculté de médecine de La Timone, 27, boulevard Jean-Moulin, 13385 Marseille cedex 05, France. Brigitte.Granel@medecine.unive-mrs.fr
La Revue De Medecine Interne
|April 12, 2005
Summary
This review examines genetic factors influencing systemic sclerosis fibrosis. Identifying these genetic links can reveal new therapeutic targets for this autoimmune disorder.
Area of Science:
- Rheumatology
- Immunology
- Genetics
Context:
- Systemic sclerosis is a complex autoimmune disorder.
- Pathophysiology involves autoimmunity, endothelial damage, and fibrosis.
- Genetic predisposition is suggested by familial cases and population studies.
Purpose:
- To review genetic analyses of genes implicated in systemic sclerosis fibrosis.
- Focus on genes encoding cytokines, growth factors, extracellular matrix, and vascular tone agents.
Summary:
- The review covers genetic factors in systemic sclerosis (SSc) fibrosis.
- Investigated genes include those for TNF-alpha, IL-1, TGF-beta, collagen, and ACE.
- Analysis extends to chemokines, fibrillin, fibronectin, and NO synthase.
Impact:
- Identifying genetic susceptibility factors enhances understanding of SSc pathophysiology.
- This knowledge can guide the development of novel immunomodulatory therapies.
- Potential for targeted treatments similar to those used in rheumatoid arthritis.